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Bcl-2 Polyclonal Antibody

货号: BS65629

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS65629

Product Name :Bcl-2 Polyclonal Antibody

Swiss-Prot :P10415

Host :Rabbit

Reactivity :Human, Mouse, Rat,

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Bcl-2 Polyclonal Antibody detects endogenous levels of Bcl-2 protein.

BiowMW :~ 28 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN.

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BCL2.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of BCL2 expression in H9C2 (A), CT26 (B), MCF7 (C), HepG2 (D) whole cell lysates.

Immunohistochemical analysis of BCL2 staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of BCL2 staining in HepG2 cells.

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Curdione Inhibits Proliferation of MCF-7 Cells by Inducing Apoptosis

JournalAsian Pacific Journal of Cancer Prevention

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Preservation solution protects isolated hair micrografts by inhibiting apoptosis of hair bulb

Journal10.1016/j.lfs.2024.123292

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SpeciesHuman

PMID39643038