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Phospho-Progesterone Receptor(Ser190) Polyclonal Antibody

货号: BS65628

价格：￥ ——

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65628

Product Name :Phospho-Progesterone Receptor(Ser190) Polyclonal Antibody

Swiss-Prot :Q63449

Host :Rabbit

Reactivity :Mouse,Rat,Cow,

Applications :WB

Application_all :WB=1:500-2000

Background :Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody detects endogenous levels of Phospho-Progesterone Receptor protein only when phosphorylated at Ser190

BiowMW :110 kD/ 120kD

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PGR(phospho S190); NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_RAT.

Immunogen :KLH conjugated Synthesised phosphopeptide derived from rat Progesterone Receptor around the phosphorylation site of Ser190

Conjugate :Unconjugated

Modification :Phosphorylation

Sample: Lane 1: Uterus (Mouse) Lysate at 40 ug Lane 2: Testis (Mouse) Lysate at 40 ug Lane 3: Testis (Rat) Lysate at 40 ug Lane 4: MCF-7 (Human) Cell Lysate at 30 ug Lane 5: HepG2 (Human) Cell Lysate at 30 ug Lane 6: Hela (Human) Cell Lysate at 30 ug Primary: Anti-progesterone receptor at 1/1000 dilution

Sample: Lane 1: MCF-7 (Human) Cell Lysate at 30 ug Lane 2: Uterus (Mouse) Lysate at 40 ug Primary: Anti-Phospho-Progesterone Receptor (Ser190) at 1/1000 dilution