Product Name :Phospho-PIM1 (Tyr309) Polyclonal Antibody
Reactivity :Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,
Application_all :Flow-Cyt=1ug/Test
Background :The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011].
Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purification&Purity :affinity purified by Protein A
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Phospho-PIM1 (Tyr309) Polyclonal Antibody detects endogenous levels of Phospho-PIM1 protein only when phosphorylated at Tyr309
Note :For research use only, not for use in diagnostic procedure.
Pathway :Examples of Crosstalk Between Post-translational Modifications,
Alternative Name :PIM1 (phospho Y309); PIM1 (phospho Tyr309); Oncogene PIM 1; Oncogene PIM1; PIM 1; Pim 1 kinase; Pim 1 oncogene; PIM; Pim2; PIM3; Proto oncogene serine/threonine protein kinase Pim 1; Proviral integration site 1; Proviral integration site 2
Immunogen :KLH conjugated Synthesised phosphopeptide derived from human PIM1 around the phosphorylation site of Tyr309
Modification :Phosphorylation
