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Bcl-2 Polyclonal Antibody

货号: BS65626

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS65626

Product Name :Bcl-2 Polyclonal Antibody

Swiss-Prot :P49950

Host :Rabbit

Reactivity :Mouse, Rat, (predicted: Human, )

Applications :WB,IHC-P,

Application_all :WB=1:500-2000

Background :The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Bcl-2 Polyclonal Antibody detects endogenous levels of Bcl-2 protein.

BiowMW :26 kD

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN.

Immunogen :KLH conjugated synthetic peptide derived from human Bcl-2

Conjugate :Unconjugated

Modification :Unmodification

Sample: Lane 1: Spleen (Rat) Lysate at 40 ug Lane 2: Bone (Rat) Lysate at 40 ug Primary: Anti- Bcl-2 at 1/1000 dilution

Sample: Lane 1: Spleen (Mouse) Lysate at 40 ug Lane 2: Lymph node (Mouse) Lysate at 40 ug Lane 3: Bone (Mouse) Lysate at 40 ug Lane 4: Thyroid gland (Mouse) Lysate at 40 ug Lane 5: Spleen (Rat) Lysate at 40 ug Primary: Anti- Bcl-2 at 1/1000 dilution

(+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model

JournalBRAIN RESEARCH

ApplicationWB

IF3.61

SpeciesRat

PMID37127175
Preservation solution protects isolated hair micrografts by inhibiting apoptosis of hair bulb

Journal10.1016/j.lfs.2024.123292

ApplicationWB

IF5.2

SpeciesHuman

PMID39643038