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Phospho-PERK (Thr980) Polyclonal Antibody

货号: BS65625

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS65625

Product Name :Phospho-PERK (Thr980) Polyclonal Antibody

Swiss-Prot :Q9NZJ5

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:100~1:200

Background :The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010].

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phospho-PERK (Thr980) Polyclonal Antibody detects endogenous levels of Phospho-PERK protein only when phosphorylated at Thr980

BiowMW :~ 140 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :p-PERK(Thr980); PERK(Phospho Thr980); PERK(Phospho T980); HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS; DKFZp781H1925; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Heme regulated EIF2 alpha kinase.

Immunogen :KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding T980 of human PERK protein.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of PERK (Phospho-T980) expression in A375 (A), MCF7 (B), mouse testis (C) whole cell lysates.

Immunohistochemical analysis of PERK (Phospho-T980) staining in human lung cancer formalin fixed paraffin embedded tissue section.