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phospho-p53BP1 (Ser25 + Ser29)Polyclonal Antibody

货号: BS65621

价格：￥ ——

货期：现货（1-2个工作日）

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No. :BS65621

Product Name :phospho-p53BP1 (Ser25 + Ser29)Polyclonal Antibody

Swiss-Prot :Q12888

Host :Rabbit

Reactivity :Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,

Applications :IHC-P,

Application_all :IHC-P=1:100-500

Background :p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :phospho-p53BP1 (Ser25 + Ser29) Polyclonal Antibody detects endogenous levels of phospho-p53BP1 protein only when phosphorylated at Ser25 + Ser29.

BiowMW :213kD

Note :For research use only, not for use in diagnostic procedure.

Pathway :Cell Cycle G2 M DNA Damage Signaling Pathway,

Alternative Name :53BP1 (phospho S25); p-53BP1 (phospho S25) ;53BP1 (Phospho-Ser25/29); 53BP1 (Phospho-S25/S29); phospho-p53BP1(Ser25/Ser29); P-53BP1 (Ser25/29); 53 BP1; FLJ41424; MGC138366; p202; p53 binding protein 1; p53 BP1; p53BP1; TP53 BP1; TP53BP1; Tumor protein 53 binding protein 1; Tumor protein p53 binding protein 1; Tumor suppressor p53 binding protein 1; TP53B_HUMAN; tumor protein 53-binding protein, 1.

Immunogen :KLH conjugated Synthesised phosphopeptide derived from human p53BP1 around the phosphorylation site of Ser25/29:ED(p-S)QPE(p-S)QV

Conjugate :Unconjugated

Modification :Phosphorylation

Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-p53BP1 (Ser25 + Ser29)) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C

Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-p53BP1 (Ser25 + Ser29)) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C

MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation

JournalCell Cycle

ApplicationIF,WB

IF4.534

SpeciesMouse

PMID23475131