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Klotho Polyclonal Antibody

货号: BS65616

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65616

Product Name :Klotho Polyclonal Antibody

Swiss-Prot :Q9UEF7

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB=1:500-2000

Background :May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Klotho Polyclonal Antibody detects endogenous levels of Klotho protein.

BiowMW :~ 116 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KL antibody KLOT_HUMAN; Klotho peptide

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KL (NP_004786.2).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of extracts of various cell lines, using KL antibody at 1:3000 dilution.