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IL-4R polyclonal antibody

货号: BS65584

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS65584

Product Name :IL-4R polyclonal antibody

Swiss-Prot :Q63257

Host :Rabbit

Reactivity :Mouse,Rat,

Applications :WB,

Application_all :WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

Background :This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL-4R polyclonal Antibody detects endogenous levels of IL-4R protein.

BiowMW :~140kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CD124; IL 4R alpha; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP; Il4r; IL4R nirs variant 1; IL4RA; IL4RA_HUMAN; Interleukin 4 receptor alpha chain; Interleukin 4 receptor; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha.

Immunogen :KLH conjugated synthetic peptide derived from rat IL-4R:111-210/801 <Extracellular>

Conjugate :Unconjugated

Modification :Unmodification

Anti- IL-4R at 1/1000 dilution

IL-4 mediates the delayed neurobehavioral impairments induced by neonatal hepatitis B vaccination that involves the down-regulation of the IL-4 receptor in the hippocampus

JournalCytokine

ApplicationWB

IF3.078

SpeciesMouse

PMID29751176