Product Name :DEPTOR polyclonal antibody
Reactivity :Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,
Application_all :WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Background :DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.
Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purification&Purity :affinity purified by Protein A
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :DEPTOR polyclonal Antibody detects endogenous levels of DEPTOR protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Phosphoinosotode Signaling,Glutamine Metabolism,
Alternative Name :DEP domain containing 6; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; DEPDC6; DEPTOR; DPTOR_HUMAN.
Immunogen :KLH conjugated synthetic peptide derived from human DEPTOR:151-250/409
Modification :Unmodification
