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HMGCR monoclonal antibody

货号: BS65515

价格：￥ 1860

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65515

Product Name :HMGCR monoclonal antibody

Swiss-Prot :P04035

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

Background :HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HMGCR monoclonal Antibody detects endogenous levels of HMGCR protein.

BiowMW :~97kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :3 hydroxy 3 methylglutaryl CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3 hydroxymethylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Hydroxymethylglutaryl CoA reductase; LDLCQ3; MGC103269.

Immunogen :KLH conjugated synthetic peptide derived from human HMGCR:

Conjugate :Unconjugated

Modification :Unmodification

Anti-HMGCR at 1/1000 dilution

Downregulation of miR-150 Expression by DNA Hypermethylation Is Associated with High 2-Hydroxy-(4-methylthio)butanoic Acid-Induced Hepatic Cholesterol Accumulation in Nursery Piglets

JournalJournal Of Agricultural And Food Chemistry

ApplicationWB

IF3.571

SpeciesPig

PMID27648945