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Nebulette Polyclonal Antibody

货号: BS65465

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65465

Product Name :Nebulette Polyclonal Antibody

Swiss-Prot :O76041

Host :Rabbit

Reactivity :Human,Mouse,Rat,

Applications :WB,

Application_all :WB=1:500-2000

Background :Nebulette binds to actin and plays an important role in Z-disk assembly. It is a cardiac homolog of nebulin and its expression is abundant in cardiac muscle. Nebulette defects are assocated with non-familial idiopathic cardiacmyopathy. Nebulin and nebulette are homologous thin-filament associated proteins expressed in skeletal and cardiac muscles, respectively. Nebulette, unlike nebulin, is confined to the Z-disc region of the sarcomere and does not span the whole thin filament length. Nebulette colocalizes with α-actinin in the pre-, nascent, and mature myofibrils. A polymorphism in the actin-binding motif of nebulette is a genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (IDC), characterized by a thin-walled heart and systolic dysfunction.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :affinity purified by Protein A

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Nebulette Polyclonal Antibody detects endogenous levels of Nebulette protein.

BiowMW :116 kD

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Actin binding Z disk protein; bA56H7.1; LIM nebulette; LNEBL; NEBL; NEBL_HUMAN.

Immunogen :KLH conjugated synthetic peptide derived from human Nebulette:321-420/1014

Conjugate :Unconjugated

Modification :Unmodification

Primary: Anti- Nebulette at 1/1000 dilution

免疫沉淀（IP）