Product Name :C9orf72 Polyclonal Antibody
Reactivity :Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,
Application_all :Flow-Cyt=1ug/test
Background :Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The C9orf72 gene product has been provisionally designated C9orf72 pending further characterization. There are two isoforms of C9orf72 that are produced as a result of alternative splicing events.
Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purification&Purity :affinity purified by Protein A
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :C9orf72 Polyclonal Antibody detects endogenous levels of C9orf72 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :chromosome 9 open reading frame 72; CI072_HUMAN; MGC23980; Uncharacterized protein C9orf72.
Immunogen :KLH conjugated synthetic peptide derived from human C9orf72:391-481/481
Modification :Unmodification
