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BUB1 polyclonal antibody

货号: BS6538

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6538

Product Name :BUB1 polyclonal antibody

Swiss-Prot :O43683

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB 1:500 - 1:2000 IHC 1:50 - 1:200

Background :Human cells contain two related protein kinases, BUB1 and BUBR1, that appear to have evolved from a single ancestral BUB1 gene. Both kinases are concentrated near the surface of the kinetochore where they monitor kinetochore-microtubule interactions. BUB1 and BUBR1 bind to kinetochores and are postulated to be components of the mitotic checkpoint, which monitors kinetochore activities to determine if chromosomes have achieved alignment at the spindle equator. BUBR1 is essential for normal mitotic progression as it prevents cells from prematurely entering anaphase. BUB3 is a conserved component of the mitotic spindle assembly complex and is also involved with the essential spindle checkpoint pathway that operates during early embryogenesis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :BUB1 polyclonal antibody detects endogenous levels of BUB1 protein.

BiowMW :~ 122 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Mitotic checkpoint serine/threonine-protein kinase BUB1; hBUB1; BUB1A; BUB1; BUB1L

Immunogen :Recombinant full length Human BUB1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of BUB1 polyclonal antibody

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）