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Abl1 Polyclonal Antibody

货号: BS65364

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS65364

Product Name :Abl1 Polyclonal Antibody

Swiss-Prot :P00519

Host :Rabbit

Reactivity :Human,Mouse,Rat,Monkey

Applications :WB,IHC-p,IF(paraffin section),ELISA

Application_all :Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Background :ABL proto-oncogene 1, non-receptor tyrosine kinase(ABL1) Homo sapiens This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Abl1 Polyclonal Antibody detects endogenous levels of Abl1 protein.

BiowMW :~125 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :SAPK JNK Signaling Cascades,

Alternative Name :ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150

Immunogen :The antiserum was produced against synthesized peptide derived from human Abl. AA range:156-205

Conjugate :Unconjugated

Modification :Unmodification

Western Blot analysis of COS7 cells using Abl1 Polyclonal Antibody

Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Western blot analysis of lysates from COS7 cells, treated with Adriamycin 0.5ug/ml 24h, using Abl Antibody. The lane on the right is blocked with the synthesized peptide.