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DPYSL4 polyclonal antibody

货号: BS65335

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65335

Product Name :DPYSL4 polyclonal antibody

Swiss-Prot :O14531

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,ELISA

Application_all :Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Background :disease:Antibodies against post-translationally modified DPYSL4, also called anti-CV2 autoantibodies, are present in sera from patients with paraneoplastic neurological diseases (PND). PND are disorders of the nervous system associated with various systemic cancers which are not a direct result of the tumor mass or metastasis, but attributed to remote effects of the cancer.,function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1.,

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CRMP-3 Polyclonal Antibody detects endogenous levels of CRMP-3 protein.

BiowMW :~ 62 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DPYSL4; CRMP3; ULIP4; Dihydropyrimidinase-related protein 4; DRP-4; Collapsin response mediator protein 3; CRMP-3; UNC33-like phosphoprotein 4; ULIP-4

Immunogen :The antiserum was produced against synthesized peptide derived from human DPYSL4. AA range:91-140

Conjugate :Unconjugated

Modification :Unmodification

Western Blot analysis of LOVO cells using CRMP-3 Polyclonal Antibody

Western blot analysis of lysates from LOVO and HT-29 cells, using DPYSL4 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of the lysates from RAW264.7cells using DPYSL4 antibody.