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JHD3B polyclonal antibody

货号: BS65184

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS65184

Product Name :JHD3B polyclonal antibody

Swiss-Prot :O94953

Host :Rabbit

Reactivity :Human

Applications :IHC-p,IF(paraffin section),ELISA

Application_all :Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Background :cofactor:Binds 1 Fe(2+) ion per subunit.,domain:The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.,function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.,similarity:Belongs to the JHDM3 histone demethylase family.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 2 PHD-type zinc fingers.,similarity:Contains 2 Tudor domains.,

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :JMJD2B Polyclonal Antibody detects endogenous levels of JMJD2B protein.

BiowMW :/

Note :For research use only, not for use in diagnostic procedure.

Pathway :Epigenetic Writers and Erasers of Histone H3,

Alternative Name :KDM4B; JHDM3B; JMJD2B; KIAA0876; Lysine-specific demethylase 4B; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B

Immunogen :The antiserum was produced against synthesized peptide derived from human KDM4B. AA range:351-400

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry analysis of paraffin-embedded human brain, using JHD3B Antibody. The picture on the right is blocked with the synthesized peptide.