Product Name :Caldesmon(Phospho-Ser759)polyclonal antibody
Reactivity :Human,Mouse,Rat
Applications :IHC-p,IF(paraffin section),ELISA
Application_all :Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Background :caldesmon 1(CALD1) Homo sapiens This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Phospho-Caldesmon (S759) Polyclonal Antibody detects endogenous levels of Caldesmon protein only when phosphorylated at S759.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CALD1; CAD; CDM; Caldesmon; CDM
Immunogen :The antiserum was produced against synthesized peptide derived from human Caldesmon around the phosphorylation site of Ser759. AA range:725-774
Modification :Phosphorylation
