产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

FA12(heavy chain,Cleaved-Ile20)polyclonal antibody

货号: BS65134

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS65134

Product Name :FA12(heavy chain,Cleaved-Ile20)polyclonal antibody

Swiss-Prot :P00748

Host :Rabbit

Reactivity :Human

Applications :WB,IHC-p,IF(paraffin section),ELISA

Application_all :Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Background :coagulation factor XII(F12) Homo sapiens This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activat

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cleaved-Factor XII HC (I20) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to I20.

BiowMW :~ 41 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :F12; Coagulation factor XII; Hageman factor; HAF

Immunogen :The antiserum was produced against synthesized peptide derived from human FA12. AA range:1-50

Conjugate :Unconjugated

Modification :Cleaved

Western blot analysis of FA12 (heavy chain, Cleaved-Ile20) Antibody. The lane on the right is blocked with the FA12 (heavy chain, Cleaved-Ile20) peptide.

Immunohistochemistryt analysis of paraffin-embedded human lung carcinoma, using FA12 (heavy chain, Cleaved-Ile20) Antibody. The lane on the right is blocked with the FA12 (heavy chain, Cleaved-Ile20) peptide.