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OAZ1 polyclonal antibody

货号: BS65128

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS65128

Product Name :OAZ1 polyclonal antibody

Swiss-Prot :P54368

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC-p,IF(paraffin section),ELISA

Application_all :Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Background :ornithine decarboxylase antizyme 1(OAZ1) Homo sapiens The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AZ1 Polyclonal Antibody detects endogenous levels of AZ1 protein.

BiowMW :/

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :OAZ1; OAZ; Ornithine decarboxylase antizyme 1; ODC-Az

Immunogen :The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using OAZ1 Antibody. The picture on the right is blocked with the synthesized peptide.