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SQSTM1 / p62 polyclonal antibody（KU）

货号: BS65004

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS65004

Product Name :SQSTM1 / p62 polyclonal antibody（KU）

Swiss-Prot :Q13501

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,IHC,IF

Application_all :WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background :This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SQSTM1 / p62 polyclonal antibody detects endogenous levels of SQSTM1 / p62 protein.

BiowMW :~ 62kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Autophagy Signaling,

Alternative Name :SQSTM1;A170;DMRV;FTDALS3;NADGP;OSIL;PDB3;ZIP3;p60;p62;P62b

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SQSTM1 / p62

Conjugate :Unconjugated

Modification :Unmodification

Immunoprecipitation analysis of 200ug extracts of HeLa cells, using 3 ug SQSTM1 / p62 antibody. Western blot was performed from the immunoprecipitate using SQSTM1 / p62 antibody at a dilition of 1:1000.

Western blot analysis of extracts of various cell lines, using SQSTM1 / p62 antibody at 1:1000 dilution.

Immunohistochemistry of paraffin-embedded rat kidney using SQSTM1 / p62 Antibody at dilution of 1:200 (40x lens).

Immunohistochemistry of paraffin-embedded human liver damage using SQSTM1 / p62 Antibody at dilution of 1:200 (40x lens).

Synergistic Lysosomal Impairment and ER Stress Activation for Boosted Autophagy Dysfunction Based on Te Double-Headed Nano-Bullets

JournalSmall

ApplicationWB

IF13.281

SpeciesMouse

PMID35644863
Development of Strigolactones as Novel Autophagy/Mitophagy Inhibitors against Colorectal Cancer Cells by Blocking the Autophagosome–Lysosome Fusion

JournalJOURNAL OF MEDICINAL CHEMISTRY

ApplicationWB

IF8.039

SpeciesHuman

PMID35852796
SNS alleviates depression-like behaviors in CUMS mice by regluating dendritic spines via NCOA4-mediated ferritinophagy

JournalJOURNAL OF ETHNOPHARMACOLOGY

ApplicationWB

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SpeciesMouse,Human

PMID37028613
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity

JournalBIOCHEMICAL PHARMACOLOGY

ApplicationIHC,WB

IF5.3

SpeciesMouse,Human

PMID39025409