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MEK2 polyclonal antibody

货号: BS6472

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS6472

Product Name :MEK2 polyclonal antibody

Swiss-Prot :P36507

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:2000 IHC: 1:50~1:200

Background :MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MEK2 polyclonal antibody detects endogenous levels of MEK2 protein.

BiowMW :~ 53 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Warburg Effect,G Protein-coupled Receptors Signaling to MAPK Erk,

Alternative Name :Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2; MAP2K2; MEK-2; MKK2; PRKMK2

Immunogen :Recombinant full length Human MEK2.

Conjugate :Unconjugated

Modification :Unmodification

WesternBlot (WB) analysis of MEK2 polyclonal antibody

Immunohistochemistry (IHC) analysis of MEK2 pAb in paraffin-embedded Human Stomach Cancer tissue.

MEK1–ERKs signal cascade is required for the replication of Enterovirus 71 (EV71)

JournalAntiviral Research

ApplicationIF

IF4.101

SpeciesHuman

PMID22101247