产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

CDK4 polyclonal antibody

货号: BS6462

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6462

Product Name :CDK4 polyclonal antibody

Swiss-Prot :P11802

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Background :Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2–Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Cdk4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin upregulates Cdk4 activity, whereas binding to the Cdk inhibitor p16 downregulates Cdk4 activity. Activation of the Cdk4-cyclin complexes requires phosphorylation on a single threonyl residue of Cdk4, catalyzed by a Cdk-activating protein (CAK)

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CDK4 polyclonal antibody detects endogenous levels of CDK4 protein.

BiowMW :~ 34 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Cell Cycle Control G1 S Checkpoint,

Alternative Name :Cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3; PSKJ3; CDK4

Immunogen :Recombinant full length Human CDK4.

Conjugate :Unconjugated

Modification :Unmodification

WesternBlot (WB) analysis of CDK4 polyclonal antibody

Immunohistochemistry (IHC) analysis of CDK4 pAb in paraffin-embedded Human Esophageal Cancer tissue.

Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms

JournalEuropean Journal Of Pharmacology

ApplicationWB

IF3.17

SpeciesRat

PMID28867608
Oxymatrine targets EGFRp-Tyr845 and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells

JournalCancer Chemotherapy And Pharmacology

ApplicationWB

IF3.008

SpeciesHuman

PMID25527205
TPX2 Level Correlates with Hepatocellular Carcinoma Cell Proliferation, Apoptosis, and EMT

JournalDigestive Diseases And Sciences

ApplicationWB

IF2.937

SpeciesHuman

PMID26025609
Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of Υ-synuclein in hepatocellular carcinoma cells

JournalOncotarget

ApplicationWB

IF0

SpeciesHuman

PMID28035067
ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway

JournalFrontiers in Oncology

ApplicationWB

IF6.244

SpeciesHuman

PMID33598419