产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

DSCR1 (Phospho-S108) polyclonal antibody

货号: BS64573

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS64573

Product Name :DSCR1 (Phospho-S108) polyclonal antibody

Swiss-Prot :P53805

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB:1:500~1:1000

Background :Calcipressin-1, also known as DSCR1 (Down syndrome critical region 1), Adapt78, MCIP1 (myocyte-enriched calcineurin-interacting protein 1) or regulator of calcineurin 1, is a 252 amino acid protein that belongs to the RCAN family and exists as four alternatively spliced isoforms. Abundantly expressed in skeletal muscle, brain and heart, DSCR 1 is thought to influence cardiac and nervous system development. Overexpression of DSCR1 may play a role in the pathogenesis of Down syndrome. DSCR1 interacts with Raf-1 and has been observed to inhibit calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. The gene encoding DSCR 1 maps to human chromosome 21, which which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DSCR1 (Phospho-S108) polyclonal antibody detects endogenous levels of DSCR1 protein only when phosphorylated at Ser108.

BiowMW :~ 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Calcipressin 1; Calcipressin1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1; RCAN1; ADAPT78; CSP1; DSC1; DSCR1

Immunogen :Synthetic phosphopeptide derived from human DSCR1 around the phosphorylation site of Serine 108.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of DSCR1 (Phospho-S108) polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate LaneB:Jurkat whole cell lysate LaneC:NIH3T3 whole cell lysate LaneD:CT26 whole cell lysate