产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

HP1 alpha (Phospho-S92) polyclonal antibody

货号: BS64568

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS64568

Product Name :HP1 alpha (Phospho-S92) polyclonal antibody

Swiss-Prot :P45973

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB:1:500~1:1000 IHC:1:50~1:200

Background :Heterochromatin protein 1 (HP1) is a family of heterochromatic adaptor molecules involved in both gene silencing and higher order chromatin structure. All three HP1 family members (α, β, and γ) are primarily associated with centromeric heterochromatin; however, HP1β and γ also localize to euchromatic sites in the genome. HP1 proteins are approximately 25 kDa in size and contain a conserved amino-terminal chromodomain, followed by a variable hinge region and a conserved carboxy-terminal chromoshadow domain. The chromodomain facilitates binding to histone H3 tri-methylated at Lys9, a histone "mark" closely associated with centromeric heterochromatin.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HP1 alpha (Phospho-S92) polyclonal antibody detects endogenous levels of HP1 alpha protein only when phosphorylated at Ser92.

BiowMW :~ 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Examples of Crosstalk Between Post-translational Modifications,DNA Methylation,

Alternative Name :Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha; HP1α; CBX5; HP1A

Immunogen :Synthetic phosphopeptide derived from human HP1 alpha around the phosphorylation site of Serine 92.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of HP1 alpha (Phospho-S92) polyclonal antibody at 1:500 dilution LaneA:PC3 whole cell lysate LaneB:The Heart tissue lysate of Mouse LaneC:The Brain tissue lysate of Mouse LaneD:The Heart tissue lysate of Rat