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PKC beta (Phospho-S661) polyclonal antibody

货号: BS64559

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS64559

Product Name :PKC beta (Phospho-S661) polyclonal antibody

Swiss-Prot :P05771

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB:1:500~1:1000 IHC:1:50~1:200

Background :PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms (α, βI, βII and γ) and novel (n) PKC isoforms (δ, ε, ζ, η and θ). Patterns of expression for each PKC isoform differs among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC δ and ε are independent of Ca2+. On the other hand, nPKC δ and ε, as well as all of the cPKC members, possess phorbol ester-binding activities and kinase activities.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PKC beta (Phospho-S661) polyclonal antibody detects endogenous levels of PKC beta protein only when phosphorylated at Ser661.

BiowMW :~ 80 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Phospholipase Signaling,G Protein-coupled Receptors Signaling to MAPK Erk,

Alternative Name :Protein kinase C beta type; PKC-B; PKC-beta; PKCB; PRKCB1; PRKCB

Immunogen :Synthetic phosphopeptide derived from human PKC beta around the phosphorylation site of Serine 661.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of PKC beta (Phospho-S661) polyclonal antibody at 1:500 dilution LaneA:The Brain tissue lysate of Mouse

免疫沉淀（IP）

免疫组织化学（IHC）