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MNK2 (Phospho-T249) polyclonal antibody

货号: BS64558

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64558

Product Name :MNK2 (Phospho-T249) polyclonal antibody

Swiss-Prot :Q9HBH9

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB:1:500~1:1000

Background :The MAPKAP kinases (for MAP kinase activated protein kinases) are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. These include the serine/threonine kinases Rsk-1 (also designated MAPKAP kinase-1), Rsk-2 and Rsk-3, which are phosphorylated by ERK1 and ERK2. Similarly, p38 phosphorylates and activates the serine/threonine kinases MAPKAP kinase-2 and MAPKAP kinase-3 (also designated 3pK). The serine/ threonine kinases Mnk1 and Mnk2 are substrates for both ERK and p38 MAP kinases. Mnk2 exists as multiple isoforms, including Mnk2a and Mnk2b, due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MNK2 (Phospho-T249) polyclonal antibody detects endogenous levels of MNK2 protein only when phosphorylated at Thr249.

BiowMW :~ 52 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Signaling Pathways Activating p38 MAP Kinase,

Alternative Name :MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2; MKNK2; GPRK7; MNK2

Immunogen :Synthetic phosphopeptide derived from human MNK2 around the phosphorylation site of Threonine 249.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of MNK2 (Phospho-T249) polyclonal antibody at 1:500 dilution LaneA:SGC7901 whole cell lysate LaneB:PC3 whole cell lysate LaneC:Jurkat whole cell lysate LaneD:The Eye tissue lysate of Mouse LaneE:The Brain tissue lysate of Rat