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MKK3 (Phospho-T222) polyclonal antibody

货号: BS64557

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64557

Product Name :MKK3 (Phospho-T222) polyclonal antibody

Swiss-Prot :P46734

Host :Rabbit

Reactivity :Human,Mouse,Zebrafish

Applications :WB IHC IF

Application_all :WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Background :The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinaseegulatory threonine and tyrosine residues present in thehr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6hosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MKK3 (Phospho-T222) polyclonal antibody detects endogenous levels of MKK3 protein only when phosphorylated at Thr222.

BiowMW :~ 40 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Signaling Pathways Activating p38 MAP Kinase,

Alternative Name :Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPKK 3; MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2; MAP2K3; MEK3; MKK3; PRKMK3; SKK2

Immunogen :Synthetic phosphopeptide derived from human MKK3 around the phosphorylation site of Threonine 222.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of MKK3 (Phospho-T222) polyclonal antibody at 1:500 dilution LaneA:Zebrafish