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PINK1 (Phospho-S228) polyclonal antibody

货号: BS64545

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS64545

Product Name :PINK1 (Phospho-S228) polyclonal antibody

Swiss-Prot :Q9BXM7

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB:1:500~1:1000

Background :PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria. PINK1 phosphorylates Parkin and promotes its translocation to mitochondria. Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson’s disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PINK1 (Phospho-S228) polyclonal antibody detects endogenous levels of PINK1 protein only when phosphorylated at Ser228.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Serine/threonine-protein kinase PINK1, mitochondrial; BRPK; PTEN-induced putative kinase protein 1; PINK1

Immunogen :Synthetic phosphopeptide derived from human PINK1 around the phosphorylation site of Serine 228.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of PINK1 (Phospho-S228) polyclonal antibody at 1:500 dilution LaneA:The Testis tissue lysate of Mouse LaneB:The Testis tissue lysate of Rat LaneC:HEK293T whole cell lysate LaneD:MCF-7 whole cell lysate LaneE:U-87MG whole cell lysate

Development of Strigolactones as Novel Autophagy/Mitophagy Inhibitors against Colorectal Cancer Cells by Blocking the Autophagosome–Lysosome Fusion

JournalJOURNAL OF MEDICINAL CHEMISTRY

ApplicationWB

IF8.039

SpeciesHuman

PMID35852796