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Kir6.2 (Phospho-T224) polyclonal antibody

货号: BS64536

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64536

Product Name :Kir6.2 (Phospho-T224) polyclonal antibody

Swiss-Prot :Q14654

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Background :ATP-sensitive K+ channels play important roles in many cellular functions by coupling cell metabolism to electrical activity. KIR6.1 and KIR6.2 are members of the KIR (inwardly rectifying potassium channel) family of potassium channels. Inward rectifying K+ channels possess a greater tendency to allow potasium to flow into the cell rather than out of it. These channels comprise two subunits: a KIR6.0 subfamily component and a SUR component, which is a member of the ATP-binding cassette protein superfamily. Mutations in the gene coding for these channels are a cause of an autosomal recessive disorder characterized by unregulated insulin secretion. The amino-terminal and carboxyl-terminal domains of KIR channel subunits are both intracellular, and the two intracellular domains of KIR6.2 physically interact with each other.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Kir6.2 (Phospho-T224) polyclonal antibody detects endogenous levels of Kir6.2 protein only when phosphorylated at Thr224.

BiowMW :~ 44 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11; KCNJ11

Immunogen :Synthetic phosphopeptide derived from human Kir6.2 around the phosphorylation site of Threonine 224.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of Kir6.2 (Phospho-T224) polyclonal antibody at 1:500 dilution LaneA:MCF-7 whole cell lysate LaneB:The Liver tissue lysate of Mouse LaneC:The Liver tissue lysate of Rat