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HER3 (Phospho-Y1222) polyclonal antibody

货号: BS64529

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64529

Product Name :HER3 (Phospho-Y1222) polyclonal antibody

Swiss-Prot :P21860

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Background :The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HER3 (Phospho-Y1222) polyclonal antibody detects endogenous levels of HER3 protein only when phosphorylated at Tyr1222.

BiowMW :~ 220 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ErbB HER Signaling,

Alternative Name :ERBB3; ERBB3 protein; erbB3 S; ERBB3; Glial growth factor receptor; HER-3; HER3; LCCS2; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; proto-oncogene-like protein c ErbB 3;

Immunogen :Synthetic phosphopeptide derived from human HER3 around the phosphorylation site of Tyrosine 1222.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot analysis of extracts of SK-BP-3 cell line, using HER3 (Phospho-Y1222) polyclonal antibody.