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FOSB (Phospho-S27) polyclonal antibody

货号: BS64527

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS64527

Product Name :FOSB (Phospho-S27) polyclonal antibody

Swiss-Prot :P53539

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IHC IF

Application_all :WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Background :Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :FOSB (Phospho-S27) polyclonal antibody detects endogenous levels of FOSB protein only when phosphorylated at Ser27.

BiowMW :~ 36 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Protein fosB; G0/G1 switch regulatory protein 3; FOSB; G0S3

Immunogen :Synthetic phosphopeptide derived from human FOSB around the phosphorylation site of Serine 27.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of FOSB (Phospho-S27) polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:U-87MG whole cell lysate LaneC:PC3 whole cell lysate