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14-3-3 zeta (Phospho-T232) polyclonal antibody

货号: BS64514

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64514

Product Name :14-3-3 zeta (Phospho-T232) polyclonal antibody

Swiss-Prot :P63104

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB:1:500~1:1000 IHC:1:50~1:200

Background :14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :14-3-3 zeta (Phospho-T232) polyclonal antibody detects endogenous levels of 14-3-3 zeta protein only when phosphorylated at Thr232.

BiowMW :~ 28 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1; YWHAZ; 14-3-3 protein zeta; 14-3-3 protein delta; 14-3-3 ζ; 14-3-3 δ; 1433Z; KCIP1; KCIP 1

Immunogen :Synthetic phosphopeptide derived from human 14-3-3 zeta around the phosphorylation site of Threonine 232.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of 14-3-3 zeta (Phospho-T232) polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:AGS whole cell lysate LaneC:The Brain tissue lysate of Rat LaneD:The Spleen tissue lysate of Rat