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MBP (phospho-T232) polyclonal antibody

货号: BS64165

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64165

Product Name :MBP (phospho-T232) polyclonal antibody

Swiss-Prot :P02686

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Myelin basic protein (MBP) is an abundant central nervous system (CNS) myelin membrane protein that plays an important role in nerve myelination. Myelin sheaths are multi-layered membranes derived from oligodendrocytes that increase the conduction velocity of axonal impulses. MBP helps to adhere the cytoplasmic leaflets of adjacent oligodendrocyte membranes to one another. Several splice variants of MBP are expressed in cells and the protein is modified following translation (i.e. phosphorylation, methylation), which suggests additional membrane adhesion functions.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MBP (phospho-T232) polyclonal antibody detects endogenous levels of MBP protein only when phosphorylated at T232..

BiowMW :~ 12-18 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Neuronal and Glial Cell Marker Atlas,

Alternative Name :Myelin basic protein; MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein; MBP

Immunogen :Synthetic phosphopeptide derived from human MBP around the phosphorylation site of Threonine 232.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of MBP (phospho-T232) polyclonal antibody at 1:500 dilution Lane1:The Brain tissue lysate of Mouse(20ug) Lane2:The Brain tissue lysate of Rat(20ug)

Clemastine improves hypomyelination in rats with hypoxic–ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway

JournalJournal of Neuroinflammation

ApplicationWB

IF5.793

SpeciesRat

PMID32061255