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p-LYN(Y397) polyclonal antibody

货号: BS64153

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS64153

Product Name :p-LYN(Y397) polyclonal antibody

Swiss-Prot :P07948

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells. Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :LYN(phospho-Y397) polyclonal antibody detects endogenous levels of LYN(phospho-Y397) protein.

BiowMW :~ 55kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,

Alternative Name :Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; LYN; JTK8

Immunogen :Synthetic peptide, corresponding to Human LYN(phospho-Y397).

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of LYN(phospho-Y397) polyclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:K562 whole cell lysate(40ug) Lane4:C6 whole cell lysate(40ug) Lane5:AML-12 whole cell lysate(40ug) Lane6:SHSY5Y whole cell lysate(40ug) Lane7:U-87MG whole cell lysate(40ug)