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XRCC6 (Acetyl-K338) polyclonal antibody

货号: BS64099

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS64099

Product Name :XRCC6 (Acetyl-K338) polyclonal antibody

Swiss-Prot :P12956

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The Ku protein islocalized in the nucleus and iscomposed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86). Ku wasfirst described as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndrome, and waslater found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cellsignaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription byvirtue of its DNA binding activity,serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer binding factor (E1BF),composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :XRCC6 (Acetyl-K338) polyclonal antibody detects endogenous levels of XRCC6 protein only when acetylated at Lys338.

BiowMW :~ 69 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6; XRCC6

Immunogen :Synthetic Acetylated peptide derived from human XRCC6 around the Acetylation site of lysine K338.

Conjugate :Unconjugated

Modification :Acetylated

Western blot (WB) analysis of XRCC6 (Acetyl-K338) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug)) Lane3:NIH-3T3 whole cell lysate(40ug) Lane4:H9C2 whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(40ug)