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TAL1 (Acetyl-K221/K222) polyclonal antibody

货号: BS64094

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64094

Product Name :TAL1 (Acetyl-K221/K222) polyclonal antibody

Swiss-Prot :P17542/Q16559

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Activation of TAL1 characterizes up to 60% ofcases of human T cell acute lymph oblastic leukemia,making it themost frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phospho protein and basic helixx-loop-helixtranscription factorknown to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box.In addition, leukemogenesisis accelerated dramatically bytransgenic coexpression of TAL1 and the catalyticsubunit ofcasein kinase IIα, a serine/threonine protein kinase known tomodulate the activity of other βHLH transcription factors.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TAL1 (Acetyl-K221/K222) polyclonal antibody detects endogenous levels of TAL1 protein only when acetylated at Lys221 and Lys222. This antibody also recognizes TAL2 protein when acetylated at Lys36 and Lys37.

BiowMW :~ 34 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL1;T-cell acute lymphocytic leukemia protein 2; TAL-2; Class A basic helix-loop-helix protein 19; bHLHa19; TAL2

Immunogen :Synthetic Acetylated peptide derived from human TAL1 around the Acetylation site of K221/K222.

Conjugate :Unconjugated

Modification :Acetylated

Western blot (WB) analysis of TAL1 (Acetyl-K221/K222) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug)) Lane3:PC12 whole cell lysate(40ug) Lane4:MCF-7 whole cell lysate(40ug)