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SMAD2/3 (Acetyl-K19) polyclonal antibody

货号: BS64092

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64092

Product Name :SMAD2/3 (Acetyl-K19) polyclonal antibody

Swiss-Prot :P84022/Q15796

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGF∫/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad proteins.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SMAD2/3 (Acetyl-K19) polyclonal antibody detects endogenous levels of SMAD2/3 protein only when acetylated at Lys19.

BiowMW :~ 89 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Cell Cycle Control G1 S Checkpoint,Contribution of Soluble Factors to EMT,hippo Signaling,hippo Signaling,

Alternative Name :Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3; MADH3

Immunogen :Synthetic peptide derived from humanSMAD2/3 around the acetylated at Lys19.

Conjugate :Unconjugated

Modification :Acetylated

Western blot (WB) analysis of SMAD2/3 (Acetyl-K19) polyclonal antibody at 1:500 dilution Lane1:PC12 whole cell lysate(40ug) Lane2:NIH-3T3 whole cell lysate(40ug) Lane3:Hela whole cell lysate(40ug)