产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

TSC2 (phospho-T1462) polyclonal antibody

货号: BS64040

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS64040

Product Name :TSC2 (phospho-T1462) polyclonal antibody

Swiss-Prot :P49815

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TSC2 (phospho-T1462) polyclonal antibody detects endogenous levels of TSC2 protein only when phosphorylated at Thr1462.

BiowMW :~ 180 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :PI3K AKT signaling,Insulin &Glucose Signaling,MTOR signaling,

Alternative Name :Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4

Immunogen :A synthetic peptide corresponding to residues in Human TSC2 around the phosphorylation site of Thr1462.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-TSC2 (T1462) polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Insulin (30ng/ml,5min) Lane2:H9C2 cell lysateEGF (20ng/ml,30min) Lane3:Raw264.7 cell lysate EGF (20ng/ml,30min)