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MAX (phospho-S11) polyclonal antibody

货号: BS64009

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64009

Product Name :MAX (phospho-S11) polyclonal antibody

Swiss-Prot :P61244

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :It is now well established that the nature and relative abundance of individual subunits of different classes of transcription factors can positively or negatively regulate levels of gene expression. Myc proteins homodimerize and bind DNA poorly, if at all, at physiological levels. Max is a nuclear localized bHLH-Zip protein initially identified by screening a B cell expression library with the bHLH-Zip region of c-Myc. Max homodimers and the Myc-Max heterodimers bind the sequence CACGTG; however the binding of the hetero-dimeric complex is stronger than the Max homodimer. The Max gene products have been identified as Max and Max 9 proteins that differ by a 9 amino acid insertion N-terminal to the basic region. In contrast to Myc, which is highly regulated during progression through the cell cycle, Max is highly stable and is much more abundant than Myc. Two members of the bHLH-Zip protein family, designated Mad and Mxi1, homodimerize poorly but form heterodimeric complexes with Max that have opposing functions to Myc-Max heterodimers with respect to regulation of gene expression.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-MAX(S11) polyclonal antibody detects endogenous levels of MAX protein only when phosphorylated at Ser11.

BiowMW :~ 18 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Signaling Pathways Activating p38 MAP Kinase,

Alternative Name :Protein max; Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X; BHLHD4

Immunogen :Synthetic phosphopeptide derived from human MAX around the phosphorylation site of Serine 11.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-MAX (S11) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:Mouse heart tissue lysate Lane3:H9C2 whole cell lysate