产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

PDGFR-β (phospho-Y1009) polyclonal antibody

货号: BS64002

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS64002

Product Name :PDGFR-β (phospho-Y1009) polyclonal antibody

Swiss-Prot :P09619

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :PDGF is amitogen formesenchyme- and glia-derived cells. Itconsists of two disulfide-bonded polypeptide chains, A and B, and occurs asthree isoforms, PDGF-AA, PDGF-AB and PDGF-BB. The three isoforms bindwith different affinitiesto two receptor types, A and B,which are structurallyrelated and possess protein-tyrosine kinase domains.Ligand binding induces activation of the receptorkinases byformation of receptor dimers; the A subunit of PDGF binds onlyto A receptorswith high affinity,whereasthe B subunitcan bind to both A and B receptors. Evidence suggeststhat PDGFmayfunction as a neurotrophicfactor. The fact that PDGFtype A receptors are expressed in oligodendrocyte progenitorcellswhereas PDGFtype B receptors are expressed on neuronssuggeststhat the different isoforms of PDGF may regulate growth and differentiation of differentcell typesin the developing central nervoussystemby paracrine and autocrine routes

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-PDGFR-β (Y1009) polyclonal antibody detects endogenous levels of PDGFR-β protein only when phosphorylated at Tyr1009.

BiowMW :~ 190 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,

Alternative Name :Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; EC=2.7.10.1; Beta platelet-derived growth factor receptor Beta-type platelet-derived growth factor receptor CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD140b; PDGFRB; PDGFR, PDGFR1

Immunogen :A synthetic peptide corresponding to residues in Human PDGFR-β around the phosphorylation site of Tyrosine 1009.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-PDGFR-β (Y1009) polyclonal antibody at 1:500 dilution Lane1:A549 cell lysate treated with EGF(0.1ng/ml,30mins) Lane2:Raw264.7 cell lysate treated with EGF(0.1ng/ml,30mins) Lane3:PC12 cell lysate treated with EGF(0.1ng/ml,30mins)