Product Name :p38/MAPK14 (phospho-Y182) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:2000
Background :MAP (mitogen-activated protein) kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. p38α, p38β and p38γ, also known as MAPK14, MAPK11 and MAPK12, respectively, each contain one protein kinase domain and belong to the MAP kinase family. Expressed in different areas throughout the body with common expression patterns in heart, p38 proteins use magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins. Via their catalytic activity, p38α, p38β and p38γ are involved in a variety of events throughout the cell, including signal transduction pathways, cytokine production and cell proliferation and differentiation.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p38/MAPK14 (phospho-Y182) polyclonal antibodydetects endogenous levels of MAPK14 protein only when phosphorylated at Tyr182.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Phospholipase Signaling,Immune Cell Signaling,B cell receptor signaling,MAPK Erk in Growth and Differentiation Pathway,
Alternative Name :Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated protein kinase 2a; SAPK2a; MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A
Immunogen :Synthetic phosphopeptide derived from human p38/MAPK14 around the phosphorylation site of Tyrosine 182.
Modification :Phosphorylation
