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BID polyclonal antibody

货号: BS62558

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS62558

Product Name :BID polyclonal antibody

Swiss-Prot :P55957

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB:1:500~1:1000

Background :Bid is a pro-apoptotic “BH3 domain-only” member of the Bcl-2 family originally discovered to interact with both the anti-apoptotic family member Bcl-2 and the pro-apoptotic protein Bax. Bid is normally localized in the cytosolic fraction of cells as an inactive precursor and is cleaved at Asp60 by caspase-8 during Fas signaling, leading to translocation of the carboxyl terminal p15 fragment (tBid) to the mitochondrial outer membrane. Translocation of Bid is associated with release of cytochrome c from the mitochondria, leading to complex formation with Apaf-1 and caspase-9 and resulting in caspase-9 activation. Thus, Bid relays an apoptotic signal from the cell surface to the mitochondria triggering caspase activation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :BID polyclonal antibody detects endogenous levels of BID protein.

BiowMW :~ 21 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis,Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,Death Receptor Signaling,

Alternative Name :BH3-interacting domain death agonist; p22 BID; BID; p15 BID; p13 BID; p11 BID

Immunogen :Synthetic peptide, corresponding to Human BID.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of BID polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate

免疫沉淀（IP）

免疫组织化学（IHC）