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Myeloperoxidase 89k polyclonal antibody

货号: BS62555

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS62555

Product Name :Myeloperoxidase 89k polyclonal antibody

Swiss-Prot :P05164

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB

Application_all :WB:1:500~1:1000

Background :The heme protein myeloperoxidase (MPO) is a major component of azurophilic granules of neutrophils and polymorphonuclear leukocytes. Optimal oxygen-dependent microbiocidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products. The MPO precursor is synthesized during the promyelocytic stage of myeloid differentiation and is subsequently processed and transported intracellularly to the lysosomes. The precursor undergoes cotranslational N-linked glycosylation to produce a glycoprotein. Glucosidases in the endoplasmic reticulum (ER) or early cis Golgi convert the pro-MPO to a form which is sorted into a prelysosomal compartment, which undergoes final proteolytic maturation to native MPO, a pair of heavy-light protomers. In normal neutrophils, MPO is expressed as a dimer. Calreticulin, a calcium-binding protein residing in the ER, interacts specifically with fully glycosylated apopro-MPO. iMPO mRNA is abundant in human promyelocytic HL-60 and mouse myeloid leukemia NFS-60 cells. MPO is expressed at high levels in circulating neutrophils and monocytes but is not detectable in microglia, brain-specific macrophages or normal brain tissue.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Myeloperoxidase 89k polyclonal antibody detects endogenous levels of Myeloperoxidase 89k protein.

BiowMW :~ 89 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Myeloperoxidase; MPO; Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain

Immunogen :Synthetic peptide, corresponding to Human Myeloperoxidase 89k.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Myeloperoxidase 89k polyclonal antibody at 1:500 dilution LaneA:Jurkat whole cell lysate LaneB:K562 whole cell lysate LaneC:SP2/0 whole cell lysate