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ZNT8 polyclonal antibody

货号: BS62515

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS62515

Product Name :ZNT8 polyclonal antibody

Swiss-Prot :Q8IWU4

Host :Rabbit

Reactivity :Human,Rat

Applications :WB

Application_all :WB:1:500~1:1000

Background :Zinc, an essential element required for cell proliferation and differentiation, plays a role in a diverse array of cellular functions (such as neuroregulation) and acts as a cofactor for numerous enzymes and transcription factors. The zinc transporter (ZnT) family regulates the supply of zinc within cells, and its members commonly contain six membrane-spanning domains, a large histidine-rich intracellular loop and a C-terminal tail. ZnT-8 (zinc transporter 8), also known as SLC30A8 (solute carrier family 30 member 8), is a 369 amino acid multi-pass membrane protein that belongs to the ZnT family and is a major autoantigen in type I diabetes. Expressed specifically in pancreas islet cells, ZnT-8 functions as a zinc-efflux transporter that facilitates the accumulation of zinc in intracellular vesicles and is essential for the zinc-dependent maturation of Insulin within pancreatic cells. Multiple isoforms of ZnT-8 exist due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ZNT8 polyclonal antibody detects endogenous levels of ZNT8 protein.

BiowMW :~ 41 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Zinc transporter 8; ZnT-8; Solute carrier family 30 member 8; SLC30A8; ZNT8

Immunogen :Synthetic peptide, corresponding to Human ZNT8.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ZNT8 polyclonal antibody at 1:500 dilution LaneA:H9C2 whole cell lysate LaneB:K562 whole cell lysate

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）