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PPM1K polyclonal antibody

货号: BS62439

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS62439

Product Name :PPM1K polyclonal antibody

Swiss-Prot :Q8N3J5

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :WB IHC

Application_all :WB:1:500~1:1000 IHC:1:50~1:200

Background :PP2Cκ (protein phosphatase 2C isoform κ), also known as PP2C-type mitochondrial phosphoprotein phosphatase and PP2C domain-containing protein phosphatase 1K, is a 372 amino acid mitochondrial matrix protein that regulates the opening of mitochondrial membrane permeability transition pores. PP2Cκ is essential for cell survival, cardiac function and embryonic development. Knockdown of PP2Cκ results in cell death due to loss of mitochondrial membrane potential. PP2Cκ specifically binds to the branched-chain-αketoacid dehydrogenase (BCKD) complex and induces dephosphorylation of Ser293, effectively leading to the inhibition of branched chain amino acid metabolism. Highest expression of PP2Cκ is found in brain, diaphragm and heart. There are three isoforms of PP2Cκ that are produced as a result of alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Purification&Purity :The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

Specificity :PPM1K polyclonal antibody detects endogenous levels of PPM1K protein.

BiowMW :~ 34,36 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Protein phosphatase 1K, mitochondrial; PP2C domain-containing protein phosphatase 1K; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C isoform kappa; PP2C-kappa; PPM1K; PP2CM

Immunogen :Synthetic peptide, corresponding to Human PPM1K.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PPM1K polyclonal antibody at 1:500 dilution LaneA:A549 whole cell lysate LaneB:H1792 whole cell lysate LaneC:CT-26 whole cell lysate LaneD:PC12 whole cell lysate