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POTEG polyclonal antibody

货号: BS62434

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS62434

Product Name :POTEG polyclonal antibody

Swiss-Prot :Q6S5H5; Q6S545; A6NI47

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :WB IHC

Application_all :WB:1:500~1:1000 IHC:1:50~1:200

Background :POTE ankyrin domain family, member G ( poteg ) belongs to POTE family. The POTE family is composed of many proteins which are very closely related and expressed in prostate, ovary, testis, and placenta. Some POTE paralogs are related with some cancers. Here we showed that down‐regulation of POTEG was detected in about 60% primary esophageal squamous cell carcinoma (ESCC) tumor tissues. Clinical association studies determined that POTEG down‐regulation was significantly correlated with tumor differentiation, lymph nodes metastasis and TNM staging. Kaplan‐Meier analysis determined that POTEG down‐regulation was associated with poorer clinical outcomes of ESCC patients ( P = 0.026). Functional studies showed that POTEG overexpression could suppress tumor cell growth and metastasis capacity in vitro and in vivo. Molecular analyses revealed that POTEG downregulated CDKs, leading to subsequent inhibition of Rb phosphorylation, and consequently arrested Cell Cycle at G1/S Checkpoint.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Purification&Purity :The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

Specificity :POTEG polyclonal antibody detects endogenous levels of POTEG protein.

BiowMW :~ 58,54 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :POTE ankyrin domain family member G; ANKRD26-like family C member 2; Prostate, ovary, testis-expressed protein on chromosome 14; POTE-14; POTEG; A26C2; POTE14

Immunogen :Synthetic peptide, corresponding to Human POTEG.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of POTEG polyclonal antibody at 1:500 dilution LaneA:A549 whole cell lysate LaneB:The testis tissue lysate of Mouse LaneC:The testis tissue lysate of Rat LaneD:The brain tissue lysate of Mouse