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PNPT1 polyclonal antibody

货号: BS62427

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS62427

Product Name :PNPT1 polyclonal antibody

Swiss-Prot :Q8TCS8

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :WB IHC

Application_all :WB:1:500~1:1000 IHC:1:50~1:200

Background :Mitochondrial polyribonucleotide nucleotidyltransferase, also designated 3'-5' RNA exonuclease, OLD35, PNPase or PNPT1, is an evolutionaly conserved protein in which the mouse protein shares 90% identity with the human version. PNPase participates in mRNA degradation and hydrolyzes single-stranded ribonucleotides in the 3' to 5' direction. PNPase forms homotrimers and is upregulated in response to interferon-β induction. The N-terminus of PNPase contains a putative mitochondrial targeting sequence; mutation analysis confirms that N-terminal sequences of PNPase target the protein to the mitochondria. Endogenous PNPase also co-localizes with a mitochondrial marker protein in HeLa cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Purification&Purity :The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -24°C long term. Avoid freeze-thaw cycles.

Specificity :PNPT1 polyclonal antibody detects endogenous levels of PNPT1 protein.

BiowMW :~ 88 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Polyribonucleotide nucleotidyltransferase 1, mitochondrial; 3'-5' RNA exonuclease OLD35; PNPase old-35; Polynucleotide phosphorylase 1; PNPase 1; Polynucleotide phosphorylase-like protein; PNPT1; PNPASE

Immunogen :Synthetic peptide, corresponding to Human PNPT1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PNPT1 polyclonal antibody at 1:500 dilution LaneA:PC12 whole cell lysate LaneB:MEF whole cell lysate LaneC:A549 whole cell lysate LaneD:L02 whole cell lysate LaneE:HCT116 whole cell lysate