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SIX1 polyclonal antibody

货号: BS62393

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS62393

Product Name :SIX1 polyclonal antibody

Swiss-Prot :Q15475

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :WB

Application_all :WB:1:500~1:1000

Background :The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Sx4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Purification&Purity :The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SIX1 polyclonal antibody detects endogenous levels of SIX1 protein.

BiowMW :~ 43 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Homeobox protein SIX1; Sine oculis homeobox homolog 1; SIX1

Immunogen :Synthetic peptide, corresponding to Human SIX1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SIX1 polyclonal antibody at 1:500 dilution LaneA:PC12 whole cell lysate LaneB:MEF whole cell lysate LaneC:COS-7 whole cell lysate