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LYAR polyclonal antibody

货号: BS62329

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS62329

Product Name :LYAR polyclonal antibody

Swiss-Prot :Q9NX58

Host :Rabbit

Reactivity :Human,Rat

Applications :WB IHC

Application_all :WB:1:500~1:1000 IHC:1:50~1:200

Background :Cell growth-regulating nucleolar protein, plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'. Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity. In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines. Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :LYAR polyclonal antibody detects endogenous levels of LYAR protein.

BiowMW :~ 44 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cell growth-regulating nucleolar protein; LYAR; PNAS-5

Immunogen :Synthetic peptide, corresponding to Human LYAR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of LYAR polyclonal antibody at 1:500 dilution LaneA:C6 whole cell lysate LaneB:PC12 whole cell lysate LaneC:Hela whole cell lysate