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DOK7 polyclonal antibody

货号: BS62278

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS62278

Product Name :DOK7 polyclonal antibody

Swiss-Prot :Q18PE1

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IHC IF

Application_all :WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Background :The downstream of kinase family (Dok1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Based on their similarities, the Dok family of proteins can be divided into three subgroups: Dok-1/2/3, Dok-4/5/6 and Dok-7. Through its interaction with musclespecific receptor kinase (MuSK), Dok-7 is crucial for neuromuscular synaptogenesis and for MuSK activation. Mice lacking Dok-7 do not form neuromuscular synapses nor acetylcholine receptor clusters. Mutations in the Dok-7 gene can cause congenital myasthenic syndromes (CMA)-recessively inherited disorders characterized by muscle weakness.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DOK7 polyclonal antibody detects endogenous levels of DOK7 protein.

BiowMW :~ 53 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Protein Dok-7; Downstream of tyrosine kinase 7; DOK7; C4orf25

Immunogen :Synthetic peptide, corresponding to Human DOK7.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of DOK7 polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate LaneB:The Brain tissue lysate of Mouse LaneC:The Brain tissue lysate of Rat